NORTH TEXAS (CBSDFW.COM/CNN) — Extreme temperatures coupled with high humidity flowing from the Gulf of Mexico have set the stage for life-threatening heat in Texas, Oklahoma and other parts of the central and southern U.S.

While the Sooner and Lone Star State are no strangers to excessive heat in the heart of summer and, a little over 10 days into the season, the region is bracing for stifling heat through the upcoming holiday weekend.

Temperatures are set to feel hotter in Dallas than in Death Valley, California.

Earlier in the week, parts of Texas registered the ultimate mark of oppressive warmth. Some cities including San Antonio, Lufkin and Victoria set records for hot low temperatures, with some failing to dip below 80 degrees even in the overnight hours.

When little relief is found overnight, conditions lend themselves to dangerously hot temperatures the following day.

The seriousness of excessive heat cannot be overstated. Although hurricanes and tornadoes gain the most notoriety in the world of weather, many are surprised to learn that it is heat that is the top weather killer.

In fact, heat kills nearly twice as many Americans each year than tornadoes and almost three times more Americans than hurricanes.

Heat advisories are in effect for over 22 million Americans from Missouri to Texas, including in Oklahoma, Arkansas, and Louisiana.

Air surging in from the Gulf of Mexico will make, Dallas, Texas, reach a heat index — what it will feel like once humidity is factored in — of 110 degrees both on Wednesday and Thursday afternoon.

With these feel-like temperatures, the National Weather Service advises that heatstroke is likely within a few minutes of physical activity outdoors — or merely from prolonged exposure in the elements.

Fortunately, the human body has evolved to combat excessive heat beautifully. Sweating serves a key role in cooling your body temperature down to a safe level.

In fact, as you sweat, the process of evaporation cooling off of your skin can account for up to 22% of heat being released from your body, according to the National Center for Biotechnology Information.

However, this process is significantly hampered when humidity is so high that sweat fails to effectively evaporate.

That will be the case in cities such as Dallas, New Orleans , Oklahoma City and Tulsa in Oklahoma, Little Rock, Arkansas, and Wichita, Kansas, over the next several days.

Some valuable ways to combat the oppressive heat are through proper dress, meal choices, hydration and skin protection.

Aim to drink about half of your body weight in fluid ounces. So a 150-pound person should drink about 75 ounces of liquids per day.

Avoid alcohol for the same reasons as you should avoid high protein foods during a heatwave, they reduce your body’s natural ability to cool itself off.

If you think you will be in the elements for more than a few moments, protecting your skin with sunblock will provide more than just the obvious benefit of avoiding sunburn.

A sunburn also significantly reduces your body’s ability to cool itself off efficiently.

Choose loose-fitting clothing to improve breathability. Go for a lighter-colored attire as those will reflect and not absorb the sun’s energy, which translates to heat.

(© Copyright 2020 CBS Broadcasting Inc. All Rights Reserved. The CNN Wire™ & © 2020 Cable News Network, Inc., a Time Warner Company contributed to this report.)